- This event has passed.
November 15, 2019 4:00 pm - 5:00 pm EST
Title: Computational analysis & prediction of phenotypes… and some experiments
Speaker: Eivind Almaas, Professor, Department of Biotechnology and Food Science, NTNU – Norwegian University of Science and Technology
Date: Friday, November 15th, 2019
Time: 4:00pm – 5:00pm
Location: Northeastern University, 177 Huntington Avenue, Boston, Massachusetts 02115, 11th Floor
The challenge of inferring functional relations between an organism’s genome and its phenotypes is central to the study of biology, and there currently exists a wide variety of experimental and computational approaches to investigate these mappings. One such computational framework is that of network biology. Another relies on constraint-based optimization to study genome-scale metabolic networks to predict cellular phenotypes. While quite different, both approaches have generated promising results with actionable implications ranging from human disease to the engineering of microbes.
In this presentation, I will discuss recent work in our group on the use of differential network analysis for investigating disease. Here, we have developed two methods, CSD and CoDiNA, for the systematic analysis of multiple large-scale datasets which we have applied to identify driver genes involved in several human diseases. I will continue by discussing our recent work on genome-scale metabolic networks using constraint-based analyses. A starting point for all such studies is a metabolic reconstruction of the organism(s) in question. We have developed software and algorithms to aid both the reconstruction and the model curation process, as well as the analysis of model phenotypes. Finally, I will discuss our nascent experimental work in food science: Beer ’omics.
About the Speaker
Eivind Almaas is a Professor in the Department of Biotechnology and Food Science at the K.G. Jebsen Center for Genetic Epidemiology at NTNU – Norwegian University of Science and Technology in Trondheim, Norway.